InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grm2

Summary

InnateDB Protein

IDBP-196502.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grm2

Protein Name

glutamate receptor, metabotropic 2

Synonyms

4930441L02Rik; Gprc1b; mGluR2; mGluR7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023959

InnateDB Gene

IDBG-196500 (Grm2)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. {ECO:0000269PubMed:18297054, ECO:0000269PubMed:23129762}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite.

Disease Associations

Tissue Specificity

Detected in neurons in brain cortex (at protein level). {ECO:0000269PubMed:18297054, ECO:0000269PubMed:23129762}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001641	group II metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0014047	glutamate secretion
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005622	intracellular
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0042734	presynaptic membrane
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

MGI:1351339

InterPro

IPR000162 GPCR, family 3, metabotropic glutamate receptor
IPR000337 GPCR, family 3
IPR001234 GPCR, family 3, metabotropic glutamate receptor 3
IPR001458 GPCR, family 3, metabotropic glutamate receptor 2
IPR001828 Extracellular ligand-binding receptor
IPR002455 GPCR, family 3, gamma-aminobutyric acid receptor, type B
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF07562
PF00003

PRINTS

PR00593
PR00248
PR01053
PR01052

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14BI2