InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irf8

Summary

InnateDB Protein

IDBP-196511.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irf8

Protein Name

interferon regulatory factor 8

Synonyms

AI893568; ICSBP; Icsbp1; IRF-8; Myls;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040245

InnateDB Gene

IDBG-196509 (Irf8)

Protein Structure

UniProt Annotation

Function

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA- 3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. {ECO:0000269PubMed:22992524}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17579016}.

Disease Associations

Tissue Specificity

Predominantly in lymphoid tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 337 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.

Experimentally validated
Total	337 [view]
Protein-Protein	23 [view]
Protein-DNA	314 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	70 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006909	phagocytosis
GO:0006955	immune response
GO:0009617	response to bacterium
GO:0030099	myeloid cell differentiation
GO:0032729	positive regulation of interferon-gamma production
GO:0032735	positive regulation of interleukin-12 production
GO:0042742	defense response to bacterium
GO:0042832	defense response to protozoan
GO:0044130	negative regulation of growth of symbiont in host
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter
GO:0071222	cellular response to lipopolysaccharide