InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxo31

Summary

InnateDB Protein

IDBP-196646.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo31

Protein Name

RIKEN cDNA 1110003O08 gene

Synonyms

1110003O08Rik; 2310046N15Rik; Fbx14; Fbxo14;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057573

InnateDB Gene

IDBG-196644 (Fbxo31)

Protein Structure

UniProt Annotation

Function

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030332	cyclin binding

Biological Process

GO:0006974	cellular response to DNA damage stimulus
GO:0008054	cyclin catabolic process
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031571	mitotic G1 DNA damage checkpoint