Mus musculus Protein: Gls2 | |||||||||
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Summary | |||||||||
InnateDB Protein | IDBP-196802.6 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | Gls2 | ||||||||
Protein Name | glutaminase 2 (liver, mitochondrial) | ||||||||
Synonyms | |||||||||
Species | Mus musculus | ||||||||
Ensembl Protein | ENSMUSP00000047376 | ||||||||
InnateDB Gene | IDBG-196800 (Gls2) | ||||||||
Protein Structure | |||||||||
UniProt Annotation | |||||||||
Function | Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production (By similarity). {ECO:0000250}. | ||||||||
Subcellular Localization | Mitochondrion {ECO:0000250}. | ||||||||
Disease Associations | |||||||||
Tissue Specificity | |||||||||
Comments | |||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||
PDB ID | MGI:2143539 | ||||||||
InterPro |
IPR002110
Ankyrin repeat IPR012338 Beta-lactamase/transpeptidase-like IPR015868 Glutaminase IPR020683 Ankyrin repeat-containing domain |
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PFAM |
PF00023
PF13606 PF04960 PF11929 PF12796 |
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PRINTS |
PR01415
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PIRSF | |||||||||
SMART |
SM00248
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TIGRFAMs | |||||||||
Post-translational Modifications | |||||||||
Modification | |||||||||
Cross-References | |||||||||
SwissProt | Q571F8 | ||||||||
PhosphoSite | PhosphoSite-Q571F8 | ||||||||
TrEMBL | Q3TGF1 | ||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 216456 | ||||||||
UniGene | Mm.30102 | ||||||||
RefSeq | NP_001028436 | ||||||||
MGI ID | |||||||||
MGI Symbol | Gls2 | ||||||||
OMIM | |||||||||
CCDS | CCDS24263 | ||||||||
HPRD | |||||||||
IMGT | |||||||||
EMBL | AK165896 AK168761 AK220231 BC141115 | ||||||||
GenPept | AAI41116 BAD90156 BAE38445 BAE40597 | ||||||||