Version 5.4
Mus musculus Protein: Cfh
Summary
InnateDB Protein IDBP-196805.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cfh
Protein Name complement component factor h
Synonyms Mud-1; NOM; Sas-1; Sas1;
Species Mus musculus
Ensembl Protein ENSMUSP00000066677
InnateDB Gene IDBG-196803 (Cfh)
Protein Structure
UniProt Annotation
Function Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway. {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed by the liver and secreted in plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001851 complement component C3b binding
GO:0008201 heparin binding
Biological Process
GO:0006957 complement activation, alternative pathway
GO:0030449 regulation of complement activation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:88385
InterPro IPR000436 Sushi/SCR/CCP
PFAM PF00084
PRINTS
PIRSF
SMART SM00032
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P06909
PhosphoSite PhosphoSite-P06909
TrEMBL Q8C5S1
UniProt Splice Variant
Entrez Gene 12628
UniGene Mm.8655
RefSeq
MGI ID 2YBY
MGI Symbol Cfh
OMIM
CCDS
HPRD
IMGT
EMBL AC161408 AH001909 AK077187 BC066092 J02891 M12660
GenPept AAA37759 AAA37762 AAA37795 AAH66092 BAC36669

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca