Version 5.4
Mus musculus Gene: Cfh
Summary
InnateDB Gene IDBG-196803.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cfh
Gene Name complement component factor h
Synonyms Mud-1; NOM; Sas-1; Sas1
Species Mus musculus
Ensembl Gene ENSMUSG00000026365
Encoded Proteins
IDBP-196805
complement component factor h
IDBP-256986
complement component factor h
IDBP-256988
complement component factor h
IDBP-542029
complement component factor h
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21285368
Cfh, a complement regulatory factor, interacts with host cell surfaces as well as C3d part of C3b and plays a major in the distinguishing host from non-host surfaces during the alternatively activated complement pathway.
InnateDB Annotation from Orthologs
Summary
PMID 18190458
[Homo sapiens] CFH is a major regulatory protein that down-regulates alternative complement activation.
PMID 21285368
[Homo sapiens] CFH, a complement regulatory factor, interacts with host cell surfaces as well as C3d part of C3b and plays a major in the distinguishing host from non-host surfaces during the alternative activated complement pathway.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000000971:
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:140085855-140183411
Strand Reverse strand
Band F
Transcripts
ENSMUST00000066859 ENSMUSP00000066677
ENSMUST00000111977 ENSMUSP00000107608
ENSMUST00000111976 ENSMUSP00000107607
ENSMUST00000123238 ENSMUSP00000115166
ENSMUST00000148225
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001851 complement component C3b binding
GO:0008201 heparin binding
Biological Process
GO:0006957 complement activation, alternative pathway
GO:0030449 regulation of complement activation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000000971
View Gene Order
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_208792
Complement cascade pathway
REACT_198562
Regulation of Complement cascade pathway
REACT_230745
Immune System pathway
KEGG
mmu04610
Complement and coagulation cascades pathway
mmu05150
Staphylococcus aureus infection pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118707
Regulation of Complement cascade pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05150
Staphylococcus aureus infection pathway
INOH
PID NCI
Cross-References
SwissProt P06909
TrEMBL D6RGQ0 E9Q8H9 E9Q8I0 Q8C5S1
UniProt Splice Variant
Entrez Gene 12628
UniGene Mm.488361 Mm.8655
RefSeq NM_009888
OMIM
CCDS CCDS48388
HPRD
IMGT
MGI ID MGI:88385
MGI Symbol Cfh
EMBL AC161408 AH001909 AK077187 BC066092 J02891 M12660
GenPept AAA37759 AAA37762 AAA37795 AAH66092 BAC36669
RNA Seq Atlas 12628

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca