InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Unc5c

Summary

InnateDB Protein

IDBP-196893.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Unc5c

Protein Name

unc-5 homolog C (C. elegans)

Synonyms

B130051O18Rik; rcm; Unc5h3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074758

InnateDB Gene

IDBG-196891 (Unc5c)

Protein Structure

UniProt Annotation

Function

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. {ECO:0000269PubMed:12451134, ECO:0000269PubMed:9126743, ECO:0000269PubMed:9389662}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Note=Defects in Unc5c are the cause of rostral cerebellar malformation (Rcm). Rcm is characterized by cerebellar and midbrain defects, apparently as a result of abnormal neuronal migration. {ECO:0000269PubMed:9126743}.

Tissue Specificity

Mainly expressed in regions of differentiating neurons. Highly expressed in brain and lung. Weakly expressed in testis, ovary, spleen, thymus and bladder. Expressed at very low level in kidney, intestine and salivary gland. {ECO:0000269PubMed:9126743, ECO:0000269PubMed:9389662}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005042	netrin receptor activity
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007420	brain development
GO:0030334	regulation of cell migration
GO:0033564	anterior/posterior axon guidance
GO:0038007	netrin-activated signaling pathway
GO:0043065	positive regulation of apoptotic process

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1095412

InterPro

IPR000488 Death domain
IPR000884 Thrombospondin, type 1 repeat
IPR000906 ZU5
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011029 Death-like domain
IPR013098 Immunoglobulin I-set

PFAM

PF00531
PF00090
PF00791
PF07679

PRINTS

PIRSF

SMART

SM00005
SM00209
SM00218
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O08747