InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Unc5c

Summary

InnateDB Gene

IDBG-196891.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Unc5c

Gene Name

unc-5 homolog C (C. elegans)

Synonyms

B130051O18Rik; rcm; Unc5h3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000059921

Encoded Proteins

IDBP-196893

unc-5 homolog C (C. elegans)

IDBP-269204

unc-5 homolog C (C. elegans)

IDBP-531667

unc-5 homolog C (C. elegans)

IDBP-532875

unc-5 homolog C (C. elegans)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182168:
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:141465564-141834924

Strand

Forward strand

Band

Transcripts

ENSMUST00000075282	ENSMUSP00000074758
ENSMUST00000106236	ENSMUSP00000101843
ENSMUST00000130636	ENSMUSP00000117487
ENSMUST00000155416
ENSMUST00000151007
ENSMUST00000142762	ENSMUSP00000118212
ENSMUST00000123631

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005042	netrin receptor activity
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007420	brain development
GO:0030334	regulation of cell migration
GO:0033564	anterior/posterior axon guidance
GO:0038007	netrin-activated signaling pathway
GO:0043065	positive regulation of apoptotic process

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000182168

View Gene Order

ENSBTAG00000002084

Not yet available

Pathways

NETPATH

REACTOME

REACT_229826

Netrin-1 signaling pathway

REACT_261444

Axon guidance pathway

REACT_188576

Developmental Biology pathway

REACT_253341

Netrin mediated repulsion signals pathway

KEGG

mmu04360

Axon guidance pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22384

Netrin mediated repulsion signals pathway

REACT_22237

Netrin-1 signaling pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04360

Axon guidance pathway

INOH

PID NCI

netrin_pathway

Netrin-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.24430

RefSeq

NM_009472 XM_006501311

OMIM

CCDS

CCDS17873

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas