InnateDB Protein
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IDBP-196898.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cdc73
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Protein Name
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cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000018337
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InnateDB Gene
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IDBG-196894 (Cdc73)
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Protein Structure
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Function |
Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys- 4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Found in the adrenal gland, kidney, heart, ovary and liver. {ECO:0000269PubMed:15580289}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 89 interaction(s) predicted by orthology.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
89 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001711
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endodermal cell fate commitment
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GO:0006351
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transcription, DNA-templated
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GO:0006378
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mRNA polyadenylation
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GO:0007049
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cell cycle
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GO:0008285
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negative regulation of cell proliferation
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GO:0010390
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histone monoubiquitination
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GO:0016055
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Wnt signaling pathway
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GO:0019827
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stem cell maintenance
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GO:0030177
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positive regulation of Wnt signaling pathway
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GO:0031442
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positive regulation of mRNA 3'-end processing
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GO:0031648
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protein destabilization
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GO:0032968
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positive regulation of transcription elongation from RNA polymerase II promoter
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GO:0033523
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histone H2B ubiquitination
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GO:0045638
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negative regulation of myeloid cell differentiation
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0048147
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negative regulation of fibroblast proliferation
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GO:0050680
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negative regulation of epithelial cell proliferation
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GO:0071222
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cellular response to lipopolysaccharide
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GO:2000134
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negative regulation of G1/S transition of mitotic cell cycle
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Cellular Component |
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PDB ID |
MGI:2384876
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InterPro |
IPR007852
RNA polymerase II accessory factor, Cdc73
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PFAM |
PF05179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8JZM7
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PhosphoSite |
PhosphoSite-Q8JZM7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
214498
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UniGene |
Mm.490019
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RefSeq |
NP_666103
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MGI ID |
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MGI Symbol |
Cdc73
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OMIM |
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CCDS |
CCDS15341
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HPRD |
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IMGT |
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EMBL |
AK080861
BC027756
BC031127
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GenPept |
AAH27756
AAH31127
BAC38048
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