InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bmpr1b

Summary

InnateDB Protein

IDBP-196932.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmpr1b

Protein Name

bone morphogenetic protein receptor, type 1B

Synonyms

Acvrlk6; AI385617; ALK-6; Alk6; AV355320; BMPR-1B; BMPR-IB; CFK-43a; SKR6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096167

InnateDB Gene

IDBG-196928 (Bmpr1b)

Protein Structure

UniProt Annotation

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005025	transforming growth factor beta receptor activity, type I
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046332	SMAD binding
GO:0046872	metal ion binding

Biological Process

GO:0001502	cartilage condensation
GO:0001550	ovarian cumulus expansion
GO:0001654	eye development
GO:0002062	chondrocyte differentiation
GO:0006468	protein phosphorylation
GO:0006703	estrogen biosynthetic process
GO:0006954	inflammatory response
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0009953	dorsal/ventral pattern formation
GO:0023014	signal transduction by phosphorylation
GO:0030154	cell differentiation
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0031290	retinal ganglion cell axon guidance
GO:0035108	limb morphogenesis
GO:0042698	ovulation cycle
GO:0043010	camera-type eye development
GO:0045669	positive regulation of osteoblast differentiation
GO:0060041	retina development in camera-type eye
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:107191

InterPro

IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003605 TGF beta receptor, GS motif
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF01064
PF00069
PF07714
PF08515

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00467
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt