InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndc80

Summary

InnateDB Protein

IDBP-196984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndc80

Protein Name

NDC80 homolog, kinetochore complex component (S. cerevisiae)

Synonyms

2610020P18Rik; AV139730; HEC; HEC1; Kntc2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024851

InnateDB Gene

IDBG-196982 (Ndc80)

Protein Structure

UniProt Annotation

Function

Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in spleen, testis and thymus. {ECO:0000269PubMed:9315664}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0007052	mitotic spindle organization
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0008608	attachment of spindle microtubules to kinetochore