InnateDB Protein
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IDBP-196997.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Glrx2
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Protein Name
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glutaredoxin 2 (thioltransferase)
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Synonyms
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1700010P22Rik; AI645710; Grx2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000053443
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InnateDB Gene
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IDBG-196991 (Glrx2)
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Protein Structure
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Function |
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. {ECO:0000269PubMed:11397793, ECO:0000269PubMed:15347644}.
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Subcellular Localization |
Isoform 1: Mitochondrion.Isoform 2: Nucleus.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Highly expressed in testis, and at much lower level in kidney and brain. {ECO:0000269PubMed:12954614}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1916617
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q923X4
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PhosphoSite |
PhosphoSite-Q923X4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
69367
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UniGene |
Mm.454828
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RefSeq |
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MGI ID |
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MGI Symbol |
Glrx2
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF276918
AF380337
AK005853
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GenPept |
AAF86465
AAK85319
BAB24276
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