InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cish

Summary

InnateDB Protein

IDBP-197067.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cish

Protein Name

cytokine inducible SH2-containing protein

Synonyms

AI385595; Cis; CIS1; F17; F23;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082183

InnateDB Gene

IDBG-197065 (Cish)

Protein Structure

UniProt Annotation

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in kidney, lung and liver. Detected to a lower extent in stomach and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	27 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0009968	negative regulation of signal transduction
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth