InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cish

Summary

InnateDB Gene

IDBG-197065.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cish

Gene Name

cytokine inducible SH2-containing protein

Synonyms

AI385595; Cis; CIS1; F17; F23

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032578

Encoded Proteins

IDBP-197067

cytokine inducible SH2-containing protein

IDBP-625718

cytokine inducible SH2-containing protein

IDBP-625720

cytokine inducible SH2-containing protein

IDBP-625721

cytokine inducible SH2-containing protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19592657

[Homo sapiens] CISH is a negative regulator for inflammatory cytokine signalling that enhances NFKBIA (IKappaB-alpha) degradation and regulation and activates NF-kappaB in cholangiocytes in response to LPS stimulation.

PMID 19592657

[Homo sapiens] CISH expression in cholangiocytes is conferred by hsa-mir-98 and hsa-let-7e in response to microbial challenge, a process that may be relevant to the regulation of TLR-mediated epithelial innate immune response.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114737:
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:107296026-107302784

Strand

Forward strand

Band

Transcripts

ENSMUST00000085102	ENSMUSP00000082183
ENSMUST00000168260	ENSMUSP00000127523
ENSMUST00000165664
ENSMUST00000167072	ENSMUSP00000129941
ENSMUST00000171568	ENSMUSP00000129149

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	27 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0009968	negative regulation of signal transduction
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth