InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pan2

Summary

InnateDB Protein

IDBP-197147.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pan2

Protein Name

PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)

Synonyms

1200014O24Rik; AI047843; AW742773; mKIAA0710; Usp52;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005825

InnateDB Gene

IDBG-197145 (Pan2)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. {ECO:0000255HAMAP-Rule:MF_03182, ECO:0000269PubMed:16284618}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000255HAMAP- Rule:MF_03182, ECO:0000269PubMed:18625844}. Nucleus {ECO:0000255HAMAP-Rule:MF_03182}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000255HAMAP-Rule:MF_03182}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 318 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	318 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006397	mRNA processing
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0031251	PAN complex

Protein Structure and Domains

PDB ID

MGI:1918984

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR006055 Exonuclease
IPR012337 Ribonuclease H-like domain
IPR013520 Exonuclease, RNase T/DNA polymerase III
IPR017986 WD40-repeat-containing domain
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443
PF00929

PRINTS

PIRSF

SMART

SM00479

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BGF7