Mus musculus Gene: Pan2

Summary
InnateDB Gene IDBG-197145.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol Pan2
Gene Name PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)
Synonyms 1200014O24Rik; AI047843; AW742773; mKIAA0710; Usp52
Species Mus musculus
Ensembl Gene ENSMUSG00000005682
Encoded Proteins
IDBP-197147 PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135473:
This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10: 128303335-128321358
Strand Forward strand
Band D3
Transcripts
ENSMUST00000005825  ENSMUSP00000005825
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 318 interaction(s) predicted by orthology.
 
Predicted by orthology
Total 318 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0003676 nucleic acid binding
GO:0004221 ubiquitin thiolesterase activity
GO:0004527 exonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005515 protein binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006511 ubiquitin-dependent protein catabolic process
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSG00000135473 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000004376 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_56462 Deadenylation of mRNA
KEGG
mmu03018  RNA degradation
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20514 Deadenylation of mRNA
KEGG
hsa03018  RNA degradation
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8BGF7 
TrEMBL
UniProt Splice Variant
Entrez Gene 103135 
UniGene
RefSeq NM_133992 
OMIM
CCDS CCDS24271 
HPRD
IMGT
MGI ID MGI:1918984 
MGI Symbol Pan2
EMBL AK047887 AK089001 AK129196 AK157800 BC075686 BC079841
GenPept AAH75686  AAH79841  BAC33183  BAC40693  BAC98006  BAE34203 
ImmGen Pan2 (murine) 
RNA Seq Atlas 103135