InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pan2

Summary

InnateDB Gene

IDBG-197145.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pan2

Gene Name

PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)

Synonyms

1200014O24Rik; AI047843; AW742773; mKIAA0710; Usp52

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005682

Encoded Proteins

IDBP-197147

PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135473:
This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3\' to 5\' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:128303335-128321358

Strand

Forward strand

Band

Transcripts

ENSMUST00000005825

ENSMUSP00000005825

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 318 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	318 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006397	mRNA processing
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0031251	PAN complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000135473

View Gene Order

ENSBTAG00000004376

Not yet available

Pathways

NETPATH

REACTOME

REACT_244119

Deadenylation of mRNA pathway

REACT_233572

Gene Expression pathway

REACT_235784

Deadenylation-dependent mRNA decay pathway

KEGG

mmu03018

RNA degradation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_20514

Deadenylation of mRNA pathway

REACT_20639

Deadenylation-dependent mRNA decay pathway

REACT_71

Gene Expression pathway

KEGG

hsa03018

RNA degradation pathway

INOH

PID NCI

Cross-References

SwissProt

Q8BGF7

TrEMBL

UniProt Splice Variant

Entrez Gene

103135

UniGene

RefSeq

NM_001252326 NM_001252327 NM_133992 XM_006512985 XM_006512986 XM_006512987 XM_006512991

OMIM

CCDS

CCDS24271

HPRD

IMGT

MGI ID

MGI:1918984

MGI Symbol

Pan2

EMBL

AK047887 AK089001 AK129196 AK157800 BC075686 BC079841

GenPept

AAH75686 AAH79841 BAC33183 BAC40693 BAC98006 BAE34203

RNA Seq Atlas

103135