Version 5.4
| Mus musculus Protein: Il22ra1 | |||||||
|---|---|---|---|---|---|---|---|
| Summary | |||||||
| InnateDB Protein | IDBP-197191.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Il22ra1 | ||||||
| Protein Name | interleukin 22 receptor, alpha 1 | ||||||
| Synonyms | |||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000099605 | ||||||
| InnateDB Gene | IDBG-197189 (Il22ra1) | ||||||
| Protein Structure |
|
||||||
| UniProt Annotation | |||||||
| Function | Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. {ECO:0000269PubMed:12618864}. | ||||||
| Subcellular Localization | Membrane; Single-pass type I membrane protein. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Expressed in kidney, liver and lung. {ECO:0000269PubMed:12618864}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
|
||||||
| Gene Ontology | |||||||
Molecular Function |
|
||||||
| Biological Process |
|
||||||
| Cellular Component |
|
||||||
| Protein Structure and Domains | |||||||
| PDB ID | MGI:2663588 | ||||||
| InterPro |
IPR003961
Fibronectin, type III IPR015373 Interferon alpha/beta receptor, beta chain |
||||||
| PFAM |
PF00041
PF01108 PF09294 |
||||||
| PRINTS | |||||||
| PIRSF | |||||||
| SMART |
SM00060
|
||||||
| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q80XZ4 | ||||||
| PhosphoSite | PhosphoSite-Q80XZ4 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 230828 | ||||||
| UniGene | Mm.261647 | ||||||
| RefSeq | NP_839988 | ||||||
| MGI ID | |||||||
| MGI Symbol | Il22ra1 | ||||||
| OMIM | |||||||
| CCDS | CCDS18789 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AK141289 AL662911 AY103454 BC140972 BC140973 | ||||||
| GenPept | AAI40973 AAI40974 AAM52222 BAE24639 CAM13650 | ||||||