InnateDB Protein
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IDBP-197205.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Trafd1
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Protein Name
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TRAF type zinc finger domain containing 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000047475
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InnateDB Gene
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IDBG-197203 (Trafd1)
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Protein Structure
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Function |
Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3. {ECO:0000269PubMed:16221674, ECO:0000269PubMed:18849341}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Expressed in skeletal muscle, brain, liver, kidney, spleen and bone marrow. Expression depends on STAT1. {ECO:0000269PubMed:16221674}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1923551
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InterPro |
IPR001293
Zinc finger, TRAF-type
IPR008974
TRAF-like
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3UDK1
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PhosphoSite |
PhosphoSite-Q3UDK1
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TrEMBL |
D3Z5F4
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UniProt Splice Variant |
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Entrez Gene |
231712
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UniGene |
Mm.482853
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RefSeq |
NP_001156942
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MGI ID |
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MGI Symbol |
Trafd1
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OMIM |
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CCDS |
CCDS51638
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HPRD |
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IMGT |
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EMBL |
AC126938
AK150038
BC038396
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GenPept |
AAH38396
BAE29260
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