Version 5.4
Mus musculus Gene: Trafd1
Summary
InnateDB Gene IDBG-197203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trafd1
Gene Name TRAF type zinc finger domain containing 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000042726
Encoded Proteins
IDBP-197205
TRAF type zinc finger domain containing 1
IDBP-400293
TRAF type zinc finger domain containing 1
IDBP-533256
TRAF type zinc finger domain containing 1
IDBP-532422
TRAF type zinc finger domain containing 1
IDBP-531652
TRAF type zinc finger domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18849341
[Homo sapiens] TRAFD1 deficiency reveals its negative regulatory role in the TLR and RIG-I-like helicases signalling pathway and was found to interact with TRIF, IPS-1, TRAF3 and TRAF6 in mice
PMID 16221674
[Homo sapiens] TRAFD1 is an interferon and LPS inducible gene acting as a negative regulator of Toll-like receptor signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135148:
The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:121371725-121385632
Strand Reverse strand
Band F
Transcripts
ENSMUST00000042312 ENSMUSP00000047475
ENSMUST00000120784 ENSMUSP00000113910
ENSMUST00000156158
ENSMUST00000133138
ENSMUST00000152265 ENSMUSP00000115159
ENSMUST00000155379 ENSMUSP00000118351
ENSMUST00000146185 ENSMUSP00000117239
ENSMUST00000126550
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0034097 response to cytokine
GO:0045824 negative regulation of innate immune response
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135148
View Gene Order
ENSBTAG00000008761
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.20488 Mm.482853
RefSeq NM_001163470 NM_172275 XM_006530300 XM_006530301 XM_006530302
OMIM
CCDS CCDS51638 CCDS51639
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca