InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pla2g4a

Summary

InnateDB Protein

IDBP-197267.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pla2g4a

Protein Name

phospholipase A2, group IVA (cytosolic, calcium-dependent)

Synonyms

cPLA2; cPLA2alpha; Pla2g4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070868

InnateDB Gene

IDBG-197265 (Pla2g4a)

Protein Structure

UniProt Annotation

Function

Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

Subcellular Localization

Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004620	phospholipase activity
GO:0004622	lysophospholipase activity
GO:0004623	phospholipase A2 activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0047498	calcium-dependent phospholipase A2 activity

Biological Process

GO:0008152	metabolic process
GO:0009395	phospholipid catabolic process
GO:0042127	regulation of cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0046456	icosanoid biosynthetic process
GO:0050482	arachidonic acid secretion
GO:0071236	cellular response to antibiotic