InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyba

Summary

InnateDB Protein

IDBP-197288.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyba

Protein Name

cytochrome b-245, alpha polypeptide

Synonyms

b558; nmf333; p22-phox; p22phox;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000017604

InnateDB Gene

IDBG-197286 (Cyba)

Protein Structure

UniProt Annotation

Function

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. {ECO:0000269PubMed:19755709}.

Subcellular Localization

Cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

The strongest level of expression is found in kidney, peritoneal neutrophils and peritoneal macrophages, and a lower level in spleen and small intestine. Very low level of expression can be noted in brain, liver, testis, and heart. {ECO:0000269PubMed:2597164}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0017124	SH3 domain binding
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0003106	negative regulation of glomerular filtration by angiotensin
GO:0006801	superoxide metabolic process
GO:0006954	inflammatory response
GO:0008217	regulation of blood pressure
GO:0014895	smooth muscle hypertrophy
GO:0017004	cytochrome complex assembly
GO:0030307	positive regulation of cell growth
GO:0031667	response to nutrient levels
GO:0042493	response to drug
GO:0042554	superoxide anion generation
GO:0045087	innate immune response
GO:0045730	respiratory burst
GO:0050665	hydrogen peroxide biosynthetic process
GO:0055114	oxidation-reduction process
GO:0070555	response to interleukin-1
GO:0071230	cellular response to amino acid stimulus
GO:0071260	cellular response to mechanical stimulus
GO:0071310	cellular response to organic substance
GO:0071333	cellular response to glucose stimulus
GO:0071356	cellular response to tumor necrosis factor
GO:0071407	cellular response to organic cyclic compound
GO:0071480	cellular response to gamma radiation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030425	dendrite
GO:0043020	NADPH oxidase complex
GO:0043025	neuronal cell body
GO:0097038	perinuclear endoplasmic reticulum