InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyba

Summary

InnateDB Gene

IDBG-197286.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyba

Gene Name

cytochrome b-245, alpha polypeptide

Synonyms

b558; nmf333; p22-phox; p22phox

Species

Mus musculus

Ensembl Gene

ENSMUSG00000006519

Encoded Proteins

IDBP-197288

cytochrome b-245, alpha polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20142487

[Homo sapiens] CYBA is an NADPH oxidase and CYBA-dependent reactive oxygen species (ROS) are key regulators of neutrophil chemotactic migration.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000051523:
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:122424772-122432940

Strand

Reverse strand

Band

Transcripts

ENSMUST00000017604

ENSMUSP00000017604

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0017124	SH3 domain binding
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0003106	negative regulation of glomerular filtration by angiotensin
GO:0006801	superoxide metabolic process
GO:0006954	inflammatory response
GO:0008217	regulation of blood pressure
GO:0014895	smooth muscle hypertrophy
GO:0017004	cytochrome complex assembly
GO:0030307	positive regulation of cell growth
GO:0031667	response to nutrient levels
GO:0042493	response to drug
GO:0042554	superoxide anion generation
GO:0045087	innate immune response
GO:0045730	respiratory burst
GO:0050665	hydrogen peroxide biosynthetic process
GO:0055114	oxidation-reduction process
GO:0070555	response to interleukin-1
GO:0071230	cellular response to amino acid stimulus
GO:0071260	cellular response to mechanical stimulus
GO:0071310	cellular response to organic substance
GO:0071333	cellular response to glucose stimulus
GO:0071356	cellular response to tumor necrosis factor
GO:0071407	cellular response to organic cyclic compound
GO:0071480	cellular response to gamma radiation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030425	dendrite
GO:0043020	NADPH oxidase complex
GO:0043025	neuronal cell body
GO:0097038	perinuclear endoplasmic reticulum