InnateDB Protein
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IDBP-197395.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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P2rx1
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Protein Name
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purinergic receptor P2X, ligand-gated ion channel, 1
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Synonyms
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AI323649; BB122383; P2x; Pdcd3; RP-2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000021141
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InnateDB Gene
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IDBG-197393 (P2rx1)
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Protein Structure
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Function |
Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1098235
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InterPro |
IPR001429
P2X purinoreceptor
IPR003044
P2X1 purinoceptor
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PFAM |
PF00864
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PRINTS |
PR01307
PR01308
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P51576
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
18436
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UniGene |
Mm.25722
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RefSeq |
NP_032797
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MGI ID |
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MGI Symbol |
P2rx1
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OMIM |
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CCDS |
CCDS24992
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HPRD |
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IMGT |
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EMBL |
AF250121
AF250122
AF250123
AK035304
AL670399
X84896
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GenPept |
AAF68968
BAC29024
CAA59322
CAI24783
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