Version 5.4
Mus musculus Gene: P2rx1
Summary
InnateDB Gene IDBG-197393.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2rx1
Gene Name purinergic receptor P2X, ligand-gated ion channel, 1
Synonyms AI323649; BB122383; P2x; Pdcd3; RP-2
Species Mus musculus
Ensembl Gene ENSMUSG00000020787
Encoded Proteins
IDBP-197395
purinergic receptor P2X, ligand-gated ion channel, 1
IDBP-197397
purinergic receptor P2X, ligand-gated ion channel, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108405:
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:72999103-73015200
Strand Forward strand
Band B4
Transcripts
ENSMUST00000021141 ENSMUSP00000021141
ENSMUST00000092938 ENSMUSP00000090614
ENSMUST00000148964
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005216 ion channel activity
GO:0005261 cation channel activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
Biological Process
GO:0002554 serotonin secretion by platelet
GO:0003056 regulation of vascular smooth muscle contraction
GO:0006811 ion transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006940 regulation of smooth muscle contraction
GO:0007320 insemination
GO:0008217 regulation of blood pressure
GO:0010033 response to organic substance
GO:0019228 neuronal action potential
GO:0019229 regulation of vasoconstriction
GO:0030168 platelet activation
GO:0033198 response to ATP
GO:0034220 ion transmembrane transport
GO:0035249 synaptic transmission, glutamatergic
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042310 vasoconstriction
GO:0043270 positive regulation of ion transport
GO:0046513 ceramide biosynthetic process
GO:0051260 protein homooligomerization
GO:0051291 protein heterooligomerization
GO:0051924 regulation of calcium ion transport
Cellular Component
GO:0005639 integral component of nuclear inner membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031240 external side of cell outer membrane
GO:0043005 neuron projection
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108405
View Gene Order
ENSBTAG00000007169
Not yet available
Pathways
NETPATH
REACTOME
REACT_208483
Platelet homeostasis pathway
REACT_224553
Hemostasis pathway
REACT_215282
Platelet calcium homeostasis pathway
REACT_227667
Elevation of cytosolic Ca2+ levels pathway
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_162
Elevation of cytosolic Ca2+ levels pathway
REACT_23876
Platelet homeostasis pathway
REACT_23905
Platelet calcium homeostasis pathway
REACT_604
Hemostasis pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P51576
TrEMBL
UniProt Splice Variant
Entrez Gene 18436
UniGene Mm.25722
RefSeq NM_008771 XM_006532451 XM_006536292
OMIM
CCDS CCDS24992
HPRD
IMGT
MGI ID MGI:1098235
MGI Symbol P2rx1
EMBL AF250121 AF250122 AF250123 AK035304 AL670399 X84896
GenPept AAF68968 BAC29024 CAA59322 CAI24783
RNA Seq Atlas 18436

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca