InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: P2rx1

Summary

InnateDB Protein

IDBP-197397.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

P2rx1

Protein Name

purinergic receptor P2X, ligand-gated ion channel, 1

Synonyms

AI323649; BB122383; P2x; Pdcd3; RP-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090614

InnateDB Gene

IDBG-197393 (P2rx1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001614	purinergic nucleotide receptor activity
GO:0004931	extracellular ATP-gated cation channel activity
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005524	ATP binding

Biological Process

GO:0002554	serotonin secretion by platelet
GO:0003056	regulation of vascular smooth muscle contraction
GO:0006811	ion transport
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006940	regulation of smooth muscle contraction
GO:0007320	insemination
GO:0010033	response to organic substance
GO:0019229	regulation of vasoconstriction
GO:0030168	platelet activation
GO:0033198	response to ATP
GO:0034220	ion transmembrane transport
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0043270	positive regulation of ion transport
GO:0046513	ceramide biosynthetic process
GO:0051924	regulation of calcium ion transport

Cellular Component

GO:0005639	integral component of nuclear inner membrane
GO:0016020	membrane
GO:0031240	external side of cell outer membrane
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1098235

InterPro

IPR001429 P2X purinoreceptor
IPR003044 P2X1 purinoceptor

PFAM

PF00864

PRINTS

PR01307
PR01308

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B1AUD1

UniProt Splice Variant

Entrez Gene

18436

UniGene

Mm.25722

RefSeq

MGI ID

MGI Symbol

P2rx1

OMIM

CCDS

HPRD

IMGT

EMBL

AL670399

GenPept