InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gtf2b

Summary

InnateDB Protein

IDBP-197415.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gtf2b

Protein Name

general transcription factor IIB

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029938

InnateDB Gene

IDBG-197413 (Gtf2b)

Protein Structure

UniProt Annotation

Function

General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	9 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0017025	TBP-class protein binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:2385191

InterPro

IPR000812 Transcription factor TFIIB
IPR006671 Cyclin, N-terminal
IPR013137 Zinc finger, TFIIB-type
IPR013150 Transcription factor TFIIB, cyclin-like domain
IPR013763 Cyclin-like

PFAM

PF00134
PF08271
PF00382

PRINTS

PR00685

PIRSF

SMART

SM00385

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt