InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmgcl

Summary

InnateDB Protein

IDBP-197424.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmgcl

Protein Name

3-hydroxy-3-methylglutaryl-Coenzyme A lyase

Synonyms

AW476067; HL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030432

InnateDB Gene

IDBG-197422 (Hmgcl)

Protein Structure

UniProt Annotation

Function

Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000269PubMed:7527399}. Peroxisome {ECO:0000269PubMed:7527399}. Note=Unprocessed form is peroxisomal.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004419	hydroxymethylglutaryl-CoA lyase activity
GO:0005102	receptor binding
GO:0030145	manganese ion binding
GO:0031406	carboxylic acid binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0001889	liver development
GO:0006637	acyl-CoA metabolic process
GO:0007005	mitochondrion organization
GO:0007584	response to nutrient
GO:0042594	response to starvation
GO:0046951	ketone body biosynthetic process
GO:0051262	protein tetramerization
GO:0070542	response to fatty acid