InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hmgcl

Summary

InnateDB Gene

IDBG-197422.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmgcl

Gene Name

3-hydroxy-3-methylglutaryl-Coenzyme A lyase

Synonyms

AW476067; HL

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028672

Encoded Proteins

IDBP-197424

3-hydroxy-3-methylglutaryl-Coenzyme A lyase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117305:
The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:135946448-135962617

Strand

Forward strand

Band

Transcripts

ENSMUST00000030432	ENSMUSP00000030432
ENSMUST00000134135
ENSMUST00000151879
ENSMUST00000148613
ENSMUST00000135644

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004419	hydroxymethylglutaryl-CoA lyase activity
GO:0005102	receptor binding
GO:0030145	manganese ion binding
GO:0031406	carboxylic acid binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0001889	liver development
GO:0006637	acyl-CoA metabolic process
GO:0007005	mitochondrion organization
GO:0007584	response to nutrient
GO:0042594	response to starvation
GO:0046951	ketone body biosynthetic process
GO:0051262	protein tetramerization
GO:0070542	response to fatty acid