Version 5.4
Mus musculus Protein: Itgae
Summary
InnateDB Protein IDBP-197620.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itgae
Protein Name integrin alpha E, epithelial-associated
Synonyms A530055J10; alpha-E1; alpha-M290; aM290; CD103;
Species Mus musculus
Ensembl Protein ENSMUSP00000006101
InnateDB Gene IDBG-197618 (Itgae)
Protein Structure
UniProt Annotation
Function Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
Cellular Component
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID MGI:1298377
InterPro IPR000413 Integrin alpha chain
IPR002035 von Willebrand factor, type A
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
PFAM PF00092
PF01839
PF14312
PF08441
PF00357
PRINTS PR01185
PIRSF
SMART SM00327
SM00191
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60677
PhosphoSite PhosphoSite-Q60677
TrEMBL Q9JJJ5
UniProt Splice Variant
Entrez Gene 16407
UniGene Mm.96
RefSeq NP_032425
MGI ID
MGI Symbol Itgae
OMIM
CCDS CCDS24995
HPRD
IMGT
EMBL AB036930 AF289866 AL670399 U12236
GenPept AAC52142 AAK30302 BAB00639 CAI24788

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca