InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pa2g4

Summary

InnateDB Protein

IDBP-197873.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pa2g4

Protein Name

proliferation-associated 2G4

Synonyms

38kDa; AA672939; Ebp1; Plfap;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026425

InnateDB Gene

IDBG-197871 (Pa2g4)

Protein Structure

UniProt Annotation

Function

May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly (By similarity). Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Together with PTBP1 is required for the translation initiation on the foot- and-mouth disease virus (FMDV) IRES. {ECO:0000250, ECO:0000269PubMed:10950867, ECO:0000269PubMed:17690690}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:15064750}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003723	RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006364	rRNA processing
GO:0006417	regulation of translation
GO:0045892	negative regulation of transcription, DNA-templated