InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pa2g4

Summary

InnateDB Gene

IDBG-197871.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pa2g4

Gene Name

proliferation-associated 2G4

Synonyms

38kDa; AA672939; Ebp1; Plfap

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025364

Encoded Proteins

IDBP-197873

proliferation-associated 2G4

IDBP-533445

proliferation-associated 2G4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170515:
This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:128557766-128565934

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026425	ENSMUSP00000026425
ENSMUST00000131728	ENSMUSP00000114434
ENSMUST00000147068

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003723	RNA binding
GO:0016787	hydrolase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006364	rRNA processing
GO:0006417	regulation of translation
GO:0008152	metabolic process
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000170515

View Gene Order

ENSBTAG00000010451

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

KEGG

INOH

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

Cross-References

SwissProt

P50580

TrEMBL

Q05BN2 Q3TGU7

UniProt Splice Variant

Entrez Gene

18813

UniGene

Mm.373201 Mm.413257 Mm.490423

RefSeq

NM_011119

OMIM

CCDS

CCDS24282

HPRD

IMGT

MGI ID

MGI:894684

MGI Symbol

Pa2g4

EMBL

AK166936 AK168582 BC003777 BC005593 BC028926 BC037623 BC046532 CH466578 U43918 X84789

GenPept

AAB60513 AAH03777 AAH05593 AAH28926 AAH37623 AAH46532 BAE39129 BAE40451 CAA59260 EDL24585

RNA Seq Atlas

18813