InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bhlhe41

Summary

InnateDB Protein

IDBP-197886.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bhlhe41

Protein Name

basic helix-loop-helix family, member e41

Synonyms

6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2; Sharp1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032386

InnateDB Gene

IDBG-197884 (Bhlhe41)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. {ECO:0000269PubMed:12397359, ECO:0000269PubMed:14672706, ECO:0000269PubMed:18411297, ECO:0000269PubMed:19786558, ECO:0000269PubMed:24736997}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00380, ECO:0000255PROSITE-ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle, brain and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043425	bHLH transcription factor binding
GO:0043426	MRF binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007623	circadian rhythm
GO:0010832	negative regulation of myotube differentiation
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0032922	circadian regulation of gene expression
GO:0045892	negative regulation of transcription, DNA-templated