InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cbfa2t3

Summary

InnateDB Protein

IDBP-197915.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbfa2t3

Protein Name

core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)

Synonyms

A630044F12Rik; AI465270; AW229127; Cbfa2t3h; ETO-2; Eto2; MTGR2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006525

InnateDB Gene

IDBG-197911 (Cbfa2t3)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase- anchoring protein. {ECO:0000269PubMed:11533236, ECO:0000269PubMed:15231665, ECO:0000269PubMed:16407974}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:10022820}. Nucleus, nucleoplasm {ECO:0000269PubMed:10022820}. Golgi apparatus membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with higher expression in heart, brain, lung and spleen. Expressed in hematopoietic cells (at protein level). {ECO:0000269PubMed:10022820, ECO:0000269PubMed:15231665}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030154	cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005654	nucleoplasm
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

MGI:1338013

InterPro

IPR002893 Zinc finger, MYND-type
IPR003894 TAFH/NHR1
IPR013289 Eight-Twenty-One
IPR013292 Myeloid transforming gene on chromosome 16 (MTG16)
IPR014896 NHR2-like

PFAM

PF01753
PF07531
PF08788

PRINTS

PR01875
PR01878

PIRSF

SMART

SM00549

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt