Version 5.4
Mus musculus Gene: Cbfa2t3
Summary
InnateDB Gene IDBG-197911.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cbfa2t3
Gene Name core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
Synonyms A630044F12Rik; AI465270; AW229127; Cbfa2t3h; ETO-2; Eto2; MTGR2
Species Mus musculus
Ensembl Gene ENSMUSG00000006362
Encoded Proteins
IDBP-197913
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
IDBP-197915
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
IDBP-535150
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
IDBP-537973
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129993:
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5\'-region of the runt-related transcription factor 1 gene fused to the 3\'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:122628739-122699109
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000064674 ENSMUSP00000065728
ENSMUST00000006525 ENSMUSP00000006525
ENSMUST00000127984 ENSMUSP00000118997
ENSMUST00000134045 ENSMUSP00000117630
ENSMUST00000142535
ENSMUST00000147374
ENSMUST00000148630
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030154 cell differentiation
GO:0030851 granulocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000129993
View Gene Order
ENSBTAG00000010927
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
erbb4_pathway
ErbB4 signaling events
Cross-References
SwissProt O54972
TrEMBL B7ZP57 D3Z3P7 E9QM80
UniProt Splice Variant
Entrez Gene 12398
UniGene Mm.194339 Mm.394973 Mm.406286
RefSeq NM_001109873 NM_009824 NM_177289 XM_006530619
OMIM
CCDS CCDS22744 CCDS52696 CCDS52697
HPRD
IMGT
MGI ID MGI:1338013
MGI Symbol Cbfa2t3
EMBL AC151999 AF038029 AK033680 BC055951 BC141396 BC151156 CH466525
GenPept AAB92651 AAH55951 AAI41397 AAI51157 BAC28426 EDL11697
RNA Seq Atlas 12398

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca