InnateDB Protein
|
IDBP-197972.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Ppp1cc
|
Protein Name
|
protein phosphatase 1, catalytic subunit, gamma isoform
|
Synonyms
|
dis2m1; PP-1G; PP1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000083474
|
InnateDB Gene
|
IDBG-197968 (Ppp1cc)
|
Protein Structure
|
|
Function |
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. {ECO:0000269PubMed:21712997, ECO:0000269PubMed:21930935}.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cleavage furrow {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Nucleus speckle {ECO:0000250}. Midbody {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase. Colocalizes with SPZ1 in the nucleus. Colocalizes with URI1 at mitochondrion (By similarity). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 173 interaction(s) predicted by orthology.
Experimentally validated |
Total |
42
[view]
|
Protein-Protein |
42
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
173 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:104872
|
InterPro |
IPR004843
Calcineurin-like phosphoesterase domain, apaH type
IPR006186
Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052
Metallo-dependent phosphatase-like
|
PFAM |
PF00149
|
PRINTS |
PR00114
|
PIRSF |
|
SMART |
SM00156
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P63087
|
PhosphoSite |
PhosphoSite-P63087
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
434233
|
UniGene |
Mm.474554
|
RefSeq |
XP_006508478
|
MGI ID |
|
MGI Symbol |
Ppp1cc
|
OMIM |
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
BC010613
BC021646
BC085496
D85137
M27071
U53271
U53272
U53273
U53275
U53276
U53456
|
GenPept |
AAA37526
AAC53383
AAC53384
AAC53385
AAH10613
AAH21646
AAH85496
BAA19729
|
|
|