Version 5.4
Mus musculus Gene: Ppp1cc
Summary
InnateDB Gene IDBG-197968.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp1cc
Gene Name protein phosphatase 1, catalytic subunit, gamma isoform
Synonyms dis2m1; PP-1G; PP1
Species Mus musculus
Ensembl Gene ENSMUSG00000004455
Encoded Proteins
IDBP-197970
protein phosphatase 1, catalytic subunit, gamma isoform
IDBP-197972
protein phosphatase 1, catalytic subunit, gamma isoform
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23499489
PPP1CC dephosphorylates RNA sensors, RIG-I (DDX58) and MDA5 (IFIH1), to induce anti-viral IFNB production.
InnateDB Annotation from Orthologs
Summary
PMID 23499489
[Homo sapiens] PPP1CC dephosphorylates RNA sensors, RIG-I (DDX58) and MDA5 (IFIH1), to induce anti-viral IFNB production.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186298:
The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:122158278-122175273
Strand Forward strand
Band F
Transcripts
ENSMUST00000102528 ENSMUSP00000099587
ENSMUST00000086294 ENSMUSP00000083474
ENSMUST00000132555
ENSMUST00000128309
ENSMUST00000143218
ENSMUST00000135090
ENSMUST00000142562
ENSMUST00000151184
ENSMUST00000134719
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 173 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 173 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0005977 glycogen metabolic process
GO:0006470 protein dephosphorylation
GO:0007049 cell cycle
GO:0030182 neuron differentiation
GO:0032922 circadian regulation of gene expression
GO:0042752 regulation of circadian rhythm
GO:0043153 entrainment of circadian clock by photoperiod
GO:0045087 innate immune response (InnateDB)
GO:0051301 cell division
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016607 nuclear speck
GO:0030496 midbody
GO:0032154 cleavage furrow
GO:0043197 dendritic spine
GO:0043234 protein complex
GO:0070688 MLL5-L complex
GO:0072357 PTW/PP1 phosphatase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000186298
View Gene Order
ENSBTAG00000011198
Not yet available
Pathways
NETPATH
REACTOME
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_245618
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
REACT_215733
Downregulation of TGF-beta receptor signaling pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_189085
Disease pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_188804
Cell Cycle pathway
REACT_188937
Metabolism pathway
REACT_241408
M Phase pathway
REACT_203510
TGF-beta receptor signaling activates SMADs pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_238381
Lipid digestion, mobilization, and transport pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_202512
Mitotic Anaphase pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
KEGG
mmu04910
Insulin signaling pathway pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04720
Long-term potentiation pathway
mmu04510
Focal adhesion pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu04114
Oocyte meiosis pathway
mmu03015
mRNA surveillance pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_120727
Downregulation of TGF-beta receptor signaling pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_494
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_115566
Cell Cycle pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_111217
Metabolism pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_221739
Loss of Function of TGFBR1 in Cancer pathway
REACT_217678
Signaling by TGF-beta Receptor Complex pathway
REACT_220609
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_216366
M Phase pathway
REACT_212887
Separation of Sister Chromatids pathway
REACT_207152
Loss of Function of SMAD4 in Cancer pathway
REACT_214027
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
REACT_209241
Loss of Function of TGFBR2 in Cancer pathway
REACT_215084
Mitotic Metaphase and Anaphase pathway
REACT_211185
Mitotic Anaphase pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_214934
Cell Cycle pathway
REACT_211897
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_214353
Signal Transduction pathway
REACT_220430
TGF-beta receptor signaling activates SMADs pathway
REACT_211138
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_225632
Downregulation of TGF-beta receptor signaling pathway
REACT_209545
Resolution of Sister Chromatid Cohesion pathway
REACT_207908
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_207832
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_203101
Mitotic Prometaphase pathway
REACT_216195
Loss of Function of SMAD2/3 in Cancer pathway
REACT_220643
TGFBR1 LBD Mutants in Cancer pathway
REACT_207087
Disease pathway
REACT_209664
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_223905
TGFBR1 KD Mutants in Cancer pathway
REACT_213267
Lipid digestion, mobilization, and transport pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04720
Long-term potentiation pathway
hsa04910
Insulin signaling pathway pathway
hsa04510
Focal adhesion pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04114
Oocyte meiosis pathway
hsa03015
mRNA surveillance pathway pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
aurora_b_pathway
Aurora B signaling
insulin_glucose_pathway
Insulin-mediated glucose transport
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.280784 Mm.397825 Mm.441596 Mm.474554
RefSeq NM_013636 XM_006508415 XM_006530200 XM_006544267
OMIM
CCDS CCDS19643
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca