InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hvcn1

Summary

InnateDB Protein

IDBP-197995.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hvcn1

Protein Name

hydrogen voltage-gated channel 1

Synonyms

0610039P13Rik; AI450555; BTS; HV1; mVSOP; Vsop.;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072401

InnateDB Gene

IDBG-197993 (Hvcn1)

Protein Structure

UniProt Annotation

Function

Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. {ECO:0000269PubMed:16556803, ECO:0000269PubMed:19805063, ECO:0000269PubMed:22569364, ECO:0000269PubMed:23165764, ECO:0000269PubMed:24584463}.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Enriched in immune tissues, such as bone marrow, macrophages and spleen. {ECO:0000269PubMed:16556803}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0030171	voltage-gated proton channel activity

Biological Process

GO:0006811	ion transport
GO:0009268	response to pH
GO:0010043	response to zinc ion
GO:0015992	proton transport
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0055085	transmembrane transport
GO:0071294	cellular response to zinc ion
GO:0071467	cellular response to pH