InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nox4

Summary

InnateDB Protein

IDBP-198005.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nox4

Protein Name

NADPH oxidase 4

Synonyms

AI648021;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032781

InnateDB Gene

IDBG-198001 (Nox4)

Protein Structure

UniProt Annotation

Function

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. {ECO:0000269PubMed:10869423, ECO:0000269PubMed:11098048}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cell membrane {ECO:0000250}. Note=May localize to plasma membrane and focal adhesions. {ECO:0000250}.

Disease Associations

Tissue Specificity

EXpressed in brain, in all layers of the cerebellum, in pyramidal cells of the Ammon horn and in Purkinje cells (at protein level). Expressed in osteoclasts, leukocytes, kidney, liver and lung. {ECO:0000269PubMed:10869423, ECO:0000269PubMed:11098048, ECO:0000269PubMed:15802177}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016174	NAD(P)H oxidase activity
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0016491	oxidoreductase activity
GO:0050664	oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor
GO:0072341	modified amino acid binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001666	response to hypoxia
GO:0006801	superoxide metabolic process
GO:0007568	aging
GO:0007569	cell aging
GO:0008285	negative regulation of cell proliferation
GO:0014911	positive regulation of smooth muscle cell migration
GO:0042554	superoxide anion generation
GO:0043065	positive regulation of apoptotic process
GO:0043406	positive regulation of MAP kinase activity
GO:0045453	bone resorption
GO:0050667	homocysteine metabolic process
GO:0051496	positive regulation of stress fiber assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0055007	cardiac muscle cell differentiation
GO:0055114	oxidation-reduction process
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071320	cellular response to cAMP
GO:0071333	cellular response to glucose stimulus
GO:0071480	cellular response to gamma radiation
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0072593	reactive oxygen species metabolic process
GO:2000379	positive regulation of reactive oxygen species metabolic process
GO:2000573	positive regulation of DNA biosynthetic process

Cellular Component

GO:0001725	stress fiber
GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0005925	focal adhesion
GO:0016324	apical plasma membrane
GO:0043020	NADPH oxidase complex
GO:0048471	perinuclear region of cytoplasm
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

MGI:1354184

InterPro

IPR000778 Cytochrome b245, heavy chain
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF08022
PF08030
PF01794

PRINTS

PR00466

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JHI8