Version 5.4
Mus musculus Gene: Nox4
Summary
InnateDB Gene IDBG-198001.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nox4
Gene Name NADPH oxidase 4
Synonyms AI648021
Species Mus musculus
Ensembl Gene ENSMUSG00000030562
Encoded Proteins
IDBP-198003
NADPH oxidase 4
IDBP-198005
NADPH oxidase 4
IDBP-533615
NADPH oxidase 4
IDBP-789760
NADPH oxidase 4
IDBP-789759
NADPH oxidase 4
IDBP-789761
NADPH oxidase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18511861
[Homo sapiens] NOX4 is implicated in innate immunity since lipopolysaccharide (LPS) induces NOX4-dependent reactive oxygen species (ROS) generation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000086991:
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:87246096-87398710
Strand Forward strand
Band D3
Transcripts
ENSMUST00000068829 ENSMUSP00000070039
ENSMUST00000032781 ENSMUSP00000032781
ENSMUST00000124057 ENSMUSP00000119365
ENSMUST00000127138
ENSMUST00000124269
ENSMUST00000126887 ENSMUSP00000138336
ENSMUST00000136577 ENSMUSP00000138274
ENSMUST00000144267 ENSMUSP00000138143
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016174 NAD(P)H oxidase activity
GO:0016175 superoxide-generating NADPH oxidase activity
GO:0016491 oxidoreductase activity
GO:0050664 oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor
GO:0072341 modified amino acid binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001666 response to hypoxia
GO:0006801 superoxide metabolic process
GO:0007568 aging
GO:0007569 cell aging
GO:0008285 negative regulation of cell proliferation
GO:0014911 positive regulation of smooth muscle cell migration
GO:0042554 superoxide anion generation
GO:0043065 positive regulation of apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0045453 bone resorption
GO:0050667 homocysteine metabolic process
GO:0051496 positive regulation of stress fiber assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0055007 cardiac muscle cell differentiation
GO:0055114 oxidation-reduction process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:0071333 cellular response to glucose stimulus
GO:0071480 cellular response to gamma radiation
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072593 reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000573 positive regulation of DNA biosynthetic process
Cellular Component
GO:0001725 stress fiber
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005925 focal adhesion
GO:0016324 apical plasma membrane
GO:0043020 NADPH oxidase complex
GO:0048471 perinuclear region of cytoplasm
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000086991
View Gene Order
ENSBTAG00000018540
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
ptp1bpathway
Signaling events mediated by PTP1B
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.31748 Mm.402888 Mm.470307
RefSeq NM_001285833 NM_001285835 NM_015760 XM_006508010 XM_006508012
OMIM
CCDS CCDS21437
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca