InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpv3

Summary

InnateDB Protein

IDBP-198089.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpv3

Protein Name

transient receptor potential cation channel, subfamily V, member 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053755

InnateDB Gene

IDBG-198087 (Trpv3)

Protein Structure

UniProt Annotation

Function

Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in keratinocytes and hair follicles. {ECO:0000269PubMed:12016205}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding

Biological Process

GO:0009266	response to temperature stimulus
GO:0009408	response to heat
GO:0042636	negative regulation of hair cycle
GO:0070588	calcium ion transmembrane transport
GO:0090280	positive regulation of calcium ion import