InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clca3

Summary

InnateDB Protein

IDBP-198123.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clca3

Protein Name

chloride channel calcium activated 3

Synonyms

Clca1; Clca2; gob-5; gob5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029919

InnateDB Gene

IDBG-198121 (Clca3)

Protein Structure

UniProt Annotation

Function

May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. {ECO:0000269PubMed:11296262, ECO:0000269PubMed:11694454, ECO:0000269PubMed:16645179}.

Subcellular Localization

Secreted, extracellular space {ECO:0000269PubMed:12019299, ECO:0000269PubMed:15919655, ECO:0000269PubMed:16895902}. Note=The 75 kDa N-terminal and a 35 kDa C-terminal products are fully secreted into extracellular environment as a soluble complex of two glycoproteins.

Disease Associations

Tissue Specificity

Exclusively expressed in the digestive and respiratory tracts and in the uterus (at protein level). Expressed in small intestine, colon, stomach, and uterus and slightly expressed in trachea tissue. Exclusively expressed in the mucin granule membranes of gastrointestinal, respiratory, and uterine goblet cells and other mucin-producing cells. In the colon, expressed in the surface mucous cells. In the stomach highly expressed in the surface epithelium in the pylorus. Strongly expressed in the airway epithelium of lung tissues associated with airway hyperresponsiveness (AHR). {ECO:0000269PubMed:10049711, ECO:0000269PubMed:11296262, ECO:0000269PubMed:12019299}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0006816	calcium ion transport
GO:0006821	chloride transport
GO:0071456	cellular response to hypoxia
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005615	extracellular space
GO:0005902	microvillus
GO:0016021	integral component of membrane
GO:0030141	secretory granule
GO:0042589	zymogen granule membrane

Protein Structure and Domains

PDB ID

MGI:1346342

InterPro

IPR002035 von Willebrand factor, type A
IPR003961 Fibronectin, type III
IPR004727 Calcium-activated chloride channel protein
IPR013642 Chloride channel calcium-activated
IPR015394 Domain of unknown function DUF1973

PFAM

PF00092
PF00041
PF01108
PF08434
PF09315

PRINTS

PIRSF

SMART

SM00327
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D7Z6