InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Clca3

Summary

InnateDB Gene

IDBG-198121.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clca3

Gene Name

chloride channel calcium activated 3

Synonyms

Clca1; Clca2; gob-5; gob5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028255

Encoded Proteins

IDBP-198123

chloride channel calcium activated 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000016490:
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:145004537-145032776

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029919

ENSMUSP00000029919

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0006816	calcium ion transport
GO:0006821	chloride transport
GO:0071456	cellular response to hypoxia
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005615	extracellular space
GO:0005902	microvillus
GO:0016021	integral component of membrane
GO:0030141	secretory granule
GO:0042589	zymogen granule membrane