Version 5.4
| Mus musculus Protein: Clca5 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-198190.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Clca5 | ||||||||
| Protein Name | chloride channel calcium activated 5 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000036029 | ||||||||
| InnateDB Gene | IDBG-198188 (Clca5) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. {ECO:0000269PubMed:15284223, ECO:0000269PubMed:15292178}. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000269PubMed:15284223}; Single-pass type I membrane protein {ECO:0000269PubMed:15284223}. Basal cell membrane {ECO:0000269PubMed:15284223}; Single-pass type I membrane protein {ECO:0000269PubMed:15284223}. Cell junction {ECO:0000269PubMed:15284223}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Highly expressed in eye, spleen, lung, kidney, uterus, and endothelial cells. Weakly expressed in heart and throughout the gastrointestinal tract. Highly expressed in mammary cell lines. Its expression in immortalized cell line HC11 correlates with slow or arrested growth. Re-expression in mammary tumor cells reduces colony survival. {ECO:0000269PubMed:15284223, ECO:0000269PubMed:15292178}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2139758 | ||||||||
| InterPro |
IPR002035
von Willebrand factor, type A IPR004727 Calcium-activated chloride channel protein IPR013642 Chloride channel calcium-activated IPR015394 Domain of unknown function DUF1973 |
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| PFAM |
PF00092
PF08434 PF09315 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00327
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8BG22 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 229933 | ||||||||
| UniGene | Mm.331420 | ||||||||
| RefSeq | NP_848812 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Clca5 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS17890 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK028704 AK035512 AK048276 AY161007 BC096379 | ||||||||
| GenPept | AAH96379 AAO18366 BAC26076 BAC29086 BAC33291 | ||||||||