InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp2a2

Summary

InnateDB Protein

IDBP-198243.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp2a2

Protein Name

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

Synonyms

9530097L16Rik; D5Wsu150e; mKIAA4195; SERCA2; SERCA2B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031423

InnateDB Gene

IDBG-198239 (Atp2a2)

Protein Structure

UniProt Annotation

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform 2 is highly expressed in heart and slow twitch skeletal muscle. Isoform 2 is widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0019829	cation-transporting ATPase activity
GO:0019899	enzyme binding
GO:0044548	S100 protein binding
GO:0046872	metal ion binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006937	regulation of muscle contraction
GO:0006984	ER-nucleus signaling pathway
GO:0008152	metabolic process
GO:0045822	negative regulation of heart contraction
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0033017	sarcoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

MGI:88110

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR005782 Calcium-transporting P-type ATPase, subfamily IIA, SERCA-type
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00690
PF00689
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt