InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp2a2

Summary

InnateDB Gene

IDBG-198239.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp2a2

Gene Name

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

Synonyms

9530097L16Rik; D5Wsu150e; mKIAA4195; SERCA2; SERCA2B

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029467

Encoded Proteins

IDBP-198243

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

IDBP-725144

IDBP-725121

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174437:
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:122442702-122502225

Strand

Reverse strand

Band

Transcripts

ENSMUST00000031423	ENSMUSP00000031423
ENSMUST00000179939	ENSMUSP00000135935
ENSMUST00000177974	ENSMUSP00000136104

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0019829	cation-transporting ATPase activity
GO:0019899	enzyme binding
GO:0044548	S100 protein binding
GO:0046872	metal ion binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006937	regulation of muscle contraction
GO:0006984	ER-nucleus signaling pathway
GO:0008152	metabolic process
GO:0045822	negative regulation of heart contraction
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0033017	sarcoplasmic reticulum membrane