InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Edem3

Summary

InnateDB Protein

IDBP-198288.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Edem3

Protein Name

ER degradation enhancer, mannosidase alpha-like 3

Synonyms

2310050N11Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058941

InnateDB Gene

IDBG-198286 (Edem3)

Protein Structure

UniProt Annotation

Function

Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity. {ECO:0000269PubMed:16431915}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138, ECO:0000269PubMed:16431915}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed at higher level in liver, heart and kidney. {ECO:0000269PubMed:16431915}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004569	glycoprotein endo-alpha-1,2-mannosidase activity
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509	calcium ion binding

Biological Process

GO:0006516	glycoprotein catabolic process
GO:0006986	response to unfolded protein
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process