Version 5.4
Mus musculus Gene: Edem3
Summary
InnateDB Gene IDBG-198286.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Edem3
Gene Name ER degradation enhancer, mannosidase alpha-like 3
Synonyms 2310050N11Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000043019
Encoded Proteins
IDBP-198288
ER degradation enhancer, mannosidase alpha-like 3
IDBP-788025
ER degradation enhancer, mannosidase alpha-like 3
IDBP-788026
ER degradation enhancer, mannosidase alpha-like 3
IDBP-788027
ER degradation enhancer, mannosidase alpha-like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116406:
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:151755371-151822051
Strand Forward strand
Band G1
Transcripts
ENSMUST00000059498 ENSMUSP00000058941
ENSMUST00000188145 ENSMUSP00000140443
ENSMUST00000187951 ENSMUSP00000140775
ENSMUST00000191070 ENSMUSP00000140234
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004569 glycoprotein endo-alpha-1,2-mannosidase activity
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006516 glycoprotein catabolic process
GO:0006986 response to unfolded protein
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116406
View Gene Order
ENSBTAG00000019264
Not yet available
Pathways
NETPATH
REACTOME
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_237472
Asparagine N-linked glycosylation pathway
REACT_198606
ER Quality Control Compartment (ERQC) pathway
REACT_198618
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
REACT_198616
Calnexin/calreticulin cycle pathway
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25091
ER Quality Control Compartment (ERQC) pathway
REACT_23810
Calnexin/calreticulin cycle pathway
REACT_23878
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q2HXL6
TrEMBL
UniProt Splice Variant
Entrez Gene 66967
UniGene Mm.337691 Mm.467746
RefSeq NM_001039644 XM_006529796 XM_006529797
OMIM
CCDS CCDS35736
HPRD
IMGT
MGI ID MGI:1914217
MGI Symbol Edem3
EMBL AB188342 BC060718 BC138658 BC138659
GenPept AAH60718 AAI38659 AAI38660 BAE79485
RNA Seq Atlas 66967

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca