InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd63

Summary

InnateDB Protein

IDBP-198575.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd63

Protein Name

CD63 antigen

Synonyms

C75951; ME491; Tspan30;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026407

InnateDB Gene

IDBG-198573 (Cd63)

Protein Structure

UniProt Annotation

Function

Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269PubMed:19075008, ECO:0000269PubMed:21803846, ECO:0000269PubMed:21962903, ECO:0000269PubMed:23632027, ECO:0000269PubMed:23945142}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body {ECO:0000250}. Melanosome {ECO:0000250}. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Strongly expressed in kidney. Detected in spleen, bone marrow, peripheral blood mononuclear cells and macrophages.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002092	positive regulation of receptor internalization
GO:0007160	cell-matrix adhesion
GO:0015031	protein transport
GO:0016477	cell migration
GO:0034613	cellular protein localization
GO:0035646	endosome to melanosome transport
GO:0043473	pigmentation
GO:0048757	pigment granule maturation
GO:0050931	pigment cell differentiation
GO:1900746	regulation of vascular endothelial growth factor signaling pathway
GO:2000680	regulation of rubidium ion transport
GO:2001046	positive regulation of integrin-mediated signaling pathway

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0031226	intrinsic component of plasma membrane
GO:0031902	late endosome membrane
GO:0042470	melanosome
GO:0097487	multivesicular body, internal vesicle