InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rdh5

Summary

InnateDB Protein

IDBP-198623.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rdh5

Protein Name

retinol dehydrogenase 5

Synonyms

9-cis; AI987873; cRDH; RDH4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026406

InnateDB Gene

IDBG-198621 (Rdh5)

Protein Structure

UniProt Annotation

Function

Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all- trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP. {ECO:0000269PubMed:10588954, ECO:0000269PubMed:9539749}.

Subcellular Localization

Membrane {ECO:0000250UniProtKB:Q27979}; Peripheral membrane protein {ECO:0000250UniProtKB:Q27979}. Endoplasmic reticulum lumen {ECO:0000269PubMed:10739682}.

Disease Associations

Tissue Specificity

Expressed in eye, liver, kidney, brain, intestine, placenta, epididymus and submaxillary gland. In eye, strongly expressed in the retinal pigment epithelium, with lower expression levels detected in the inner segment of the photoreceptor cells and in the outer plexiform layer. In kidney, strong expression detected in the distal tubules and the transitional epithelium in the renal pelvis, with weaker expression detected in the epithelium of the outer stripe of the outer zone of the medulla. In liver, detected in hepatocytes in the centrilobular area. In lung, present in Clara cells in the epithelium of the bronchiole, in parenchyma and in cartilage surrounding the secondary bronchi. In skin, expressed in epidermis, hair follicles and mast cells in the dermis. Expressed in heart (PubMed:10588954 and PubMed:10739682). Not detected in heart (PubMed:9539749). Not detected in lung, spleen, skeletal muscle and testis. {ECO:0000269PubMed:10588954, ECO:0000269PubMed:10739682, ECO:0000269PubMed:9539749, ECO:0000269PubMed:9654122}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016491	oxidoreductase activity

Biological Process

GO:0007601	visual perception
GO:0008152	metabolic process
GO:0042572	retinol metabolic process
GO:0050896	response to stimulus
GO:0055114	oxidation-reduction process