InnateDB Protein
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IDBP-198703.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Smg7
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Protein Name
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Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000041241
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InnateDB Gene
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IDBG-198701 (Smg7)
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Protein Structure
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Function |
Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2682334
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InterPro |
IPR019458
Telomerase activating protein Est1
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PFAM |
PF10374
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-Q5RJH6
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TrEMBL |
Z4YJK8
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UniProt Splice Variant |
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Entrez Gene |
226517
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UniGene |
Mm.470782
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RefSeq |
NP_001153729
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MGI ID |
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MGI Symbol |
Smg7
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OMIM |
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CCDS |
CCDS48394
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HPRD |
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IMGT |
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EMBL |
AC110038
AC123613
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GenPept |
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